High Throughput Newborn Screening for Severe Combined Immunodeficiency (SCID) Using the Automated T-cell Receptor Excision Circle (TREC) in situ Assay
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چکیده
High Throughput Newborn Screening for Severe Combined Immunodeficiency (SCID) Using the Automated T-cell Receptor Excision Circle (TREC) in situ Assay R. Haughton, S. Dever, K. Turner, L. Hancock, J. Taylor, Golriz Yazdanpanah, F. Lee; Virginia Division of Consolidated Laboratory Services, Richmond, VA, Centers for Disease Control and Prevention, Atlanta, GA, RTI International, Research Triangle Park, NC
منابع مشابه
A Practical Approach to Newborn Screening for Severe Combined Immunodeficiency Using the T Cell Receptor Excision Circle Assay
Severe combined immunodeficiency (SCID) is a life-threatening condition of newborns and infants caused by defects in genes involved in T cell development. Newborn screening (NBS) for SCID using the T cell receptor excision circle (TREC) assay began in Wisconsin in 2008 and has been adopted or is being implemented by all states in 2017. It has been established that NBS using the TREC assay is ex...
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Early detection of severe combined immunodeficiency (SCID) followed by prompt treatment is critical for affected babies to live healthy lives. Newborn screening (NBS) for SCID using the T-cell receptor excision circle (TREC) test has been being performed in California for two years and around 1 million babies have been screened there. The test has demonstrated high specificity and sensitivity i...
متن کاملA multiplex immunoassay using the Guthrie specimen to detect T-cell deficiencies including severe combined immunodeficiency disease.
BACKGROUND Severe combined immunodeficiency (SCID) fulfills many of the requirements for addition to a newborn screening panel. Two newborn screening SCID pilot studies are now underway using the T-cell receptor excision circle (TREC) assay, a molecular technique. Here we describe an immunoassay with CD3 as a marker for T cells and CD45 as a marker for total leukocytes that can be used with the...
متن کاملNewborn Screening for Primary Immunodeficiency Diseases: The Past, the Present and the Future
Primary immunodeficiency diseases (PID) are a heterogeneous group of disorders caused by inborn errors of immunity, with affected children presenting with severe, recurrent or unusual infections. Over 300 distinct genetic molecular abnormalities resulting in PID have been identified, and this number continues to rise. Newborn screening for PID has been established in many countries, with the ma...
متن کاملNewborn Screening for Primary Immune Deficiencies with a TREC/KREC/ACTB Triplex Assay—A Three-Year Pilot Study in Sweden
Background: Screening newborns for severe combined immunodeficiency (SCID) has become essential, since efficient methods to identify infants with these disorders exist and early stem cell transplantation is life-saving. Method: We performed a three-year screening trial in Stockholm comprised of 89,462 newborn infants. The number of T-cell receptor excision circle (TREC)/kappa-deleting recombina...
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تاریخ انتشار 2016